Blades | Of Time -ntsc-u--ntsc-j--pal--iso-

If you are running these ISOs on RPCS3 (PS3) or Xenia (Xbox 360), region matters significantly:

The PAL version was distributed across Europe and is essential for gamers using hardware from those regions. While the "50Hz vs 60Hz" speed difference became less of an issue in the HD era (PS3/Xbox 360), PAL versions are often sought after because they frequently include multi-language support (French, German, Spanish, etc.) not found on the NTSC-U disc. The Importance of the "ISO" Blades of Time -NTSC-U--NTSC-J--PAL--ISO-

The version is the Holy Grail for many collectors of this specific title. If you are running these ISOs on RPCS3