Use Fix 1 (DLL wrapper). It works for most users, albeit with reduced performance.
The Intel SDE will intercept AVX2 instructions, translate them into multiple AVX or SSE instructions, and feed them to your CPU. The game will launch. uncharted 4 avx2 fix
Confirm CPU AVX2 support
Last-resort system changes
If you are trying to run the game on a CPU that doesn't support the AVX2 instruction set (like older Intel Core i5/i7 "Sandy Bridge" or "Ivy Bridge" processors), the game simply won't launch. But don't worry—you don't necessarily need to buy a new PC. In this guide, we will explain why this happens and the current methods to fix the Uncharted 4 AVX2 issue. Use Fix 1 (DLL wrapper)
For owners of high-end hardware from the pre-Haswell era (roughly pre-2013 Intel chips, like the beloved Ivy Bridge i7-3770K or early Xeons), the game would crash immediately upon startup. The executable was hard-coded to utilize AVX2 instructions for processing complex mathematical operations efficiently. If the processor didn't speak that specific dialect of code, the program simply had no fallback language. It was a binary gatekeeper: have AVX2, or play nothing. The game will launch
Intel’s (Software Development Emulator) can emulate AVX2 on older CPUs.