Windows Defender or antivirus software quarantined the DLL. Solution: Add the game folder to your antivirus exclusions list. Re-copy x360ce.exe and regenerate the DLL.
Even with a flawless setup, issues can occur. Here are the most frequent problems and their fixes: Tocaedit X360 Controller Emulator 3.2.8.77
x360ce current advertised version (3.2.9.81) and ... - GitHub Windows Defender or antivirus software quarantined the DLL