PDA Technical Report 82 is the definitive modern industry standard for dry heat depyrogenation. It bridges the gap
Formally titled "Low Bioburden and Aseptic Filtration of Mammalian Cell Culture Broths," PDA TR-82 was published to address a critical gap in existing regulatory guidance. While standard PDA reports (like TR-26 on sterilization filtration) focus heavily on final product sterilization, TR-82 zooms in on the unique challenges of the upstream and midstream bioprocessing steps. pda technical report 82 pdf